Scientific Research

Science. Results. Safety.

When one looks at any biologic device or product, one should know that it meets these 3 criteria. Amnion/Amnion- fluid derived biologics, as presented by Anicell Biotech, have cleared these criteria with almost 3,000 cases treated, an efficacy rate over 88%, and a 0% device complication rate.

Historically, Amnion derived treatments, have been around since 1910! A landmark study done by Lange-Consiglio et al, in 2013, showed that equine Amnion-derived therapy (vs equine bone marrow-derived) reduced re-injury rate from 23% to 4%, and reduced the time to return to normal activity by 60%. And in 2017, Larson and Gallicchio in the Journal of Cell Science and Therapy remarked:

  1. Amnion fluid and it's components are "immune privileged" – meaning it will illicit NO immune response.
  2. Amniotic Fluid contains many more progenitor cells(pluripotent) than bone marrow (multipotent).
  3. Amniotic fluid contains hyalorunic acid which aids in joint lubrication and cartilage healing.
  4. Amniotic fluid contains a full complement of growth factors that promote tissue regeneration.
  5. Amniotic fluid contains anti-inflammatory and anti-adhesion properties, thereby preventing scar tissue formation
  6. Amnniotic fluid has anti-infective properties and helps prevent infection from setting in.
  7. Amnion fluid contains cells that are able to locate damaged areas, and differentiate into many different tissue types (muscle, ligament, tendon, bone, nerve).

In summary, we have the potential to augment the healing process by implementing what Mother Nature designed:

Amniotic Mesenchymal Stromal Cells Exhibit Preferential Osteogenic and Chondrogenic Differentiation and Enhanced Matrix Production Compared With Adipose Mesenchymal Stromal CellsNatasha Topoluk, PhD,* Richard Hawkins, MD,*† John Tokish, MD,*† and  Jeremy Mercuri, PhD*‡

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832055/

 

Lange-Cosiglio 2013 study on benefits of Equine Amniotic Mesenchymal Stem Cell (v. BMSC): 

https://www.ncbi.nlm.nih.gov/pubmed/?term=lange-consiglio+cytotherapy+2013

 

Equine Amniotic Derived Stem Cells: Role and Function in Regenerative Medicine(Larson and Gallicchio):

https://www.omicsonline.org/open-access/amniotic-derived-stem-cells-role-and-function-in-regenerative-medicine-2157-7013-1000269.php?aid=88924

 

 

 

 

ASK YOURSELF THESE TWO QUESTIONS

Do you believe in regenerative therapy?

Doesn't your horse or dog deserves the best, proven, safest treatment?

Please take the time to look at the research articles, graphs and data we've accumulated below to help you answer these queries:

Amniotic Membrane-Derived Mesenchymal Cells and Their Conditioned Media: Potential Candidates for Uterine Regenerative Therapy in the Horse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216086/external link icon

Amniotic Mesenchymal Stromal Cells Exhibit Preferential Osteogenic and Chondrogenic Differentiation and Enhanced Matrix Production Compared With Adipose Mesenchymal Stromal Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832055/external link icon

Characteristics of equine mesenchymal stem cells derived from amnion and bone marrow: in vitro proliferative and multilineage potential assessment.

https://www.ncbi.nlm.nih.gov/pubmed/23527626external link icon

Characterization and differentiation of equine tendon-derived progenitor cells.

https://www.ncbi.nlm.nih.gov/pubmed/22051173external link icon

Characterization and potential applications of progenitor-like cells isolated from horse amniotic membrane.

https://www.ncbi.nlm.nih.gov/pubmed/21948689external link icon

Comparison of equine bone marrow-, umbilical cord matrix and amniotic fluid-derived progenitor cells.

https://www.ncbi.nlm.nih.gov/pubmed/21193959external link icon

Conditioned medium from horse amniotic membrane-derived multipotent progenitor cells: immunomodulatory activity in vitro and first clinical application in tendon and ligament injuries in vivo.

https://www.ncbi.nlm.nih.gov/pubmed/23795963external link icon

Equine Amniotic Microvesicles and Their Anti-Inflammatory Potential in a Tenocyte Model In Vitro.

https://www.ncbi.nlm.nih.gov/pubmed/26914245external link icon

Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719186/external link icon

Evaluation of amniotic mesenchymal cell derivatives on cytokine production in equine alveolar macrophages: an in vitro approach to lung inflammation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028987/external link icon

Investigating the efficacy of amnion-derived compared with bone marrow-derived mesenchymal stromal cells in equine tendon and ligament injuries.

https://www.ncbi.nlm.nih.gov/pubmed/23602577external link icon

Isolation and characterization of equine amniotic membrane-derived mesenchymal stem cells: We found that eAM-MSCs differentiated into osteocytes, adipocytes, and chondrocytes using specific culture media. eAM-MSCs grown under osteogenic differentiation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694186/external link icon

MicroRNAs of Equine Amniotic Mesenchymal Cell-derived Microvesicles and Their Involvement in Anti-inflammatory Processes.

https://www.ncbi.nlm.nih.gov/pubmed/29562776external link icon